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It has been shown, for example, thatC57BL/6 mice exhibit a bias toward the TH1-type immune response and are susceptibleto chronic implant-associated S. Drugs applied as eye drops may getabsorbed through the nasolacrimal duct, e.g.timolol eye drops may produce bradycardia andprecipitate asthma. On the contrary, subacute/chronic osteomyelitis may cause a rapid and even destructive infection in an immunocom-promised host. Average bone-to-plasmaAUC ratios were 0.093 in cortical and 0.241 in cancellous bone
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